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Role Description

The Principal Technology Strategist for Data Analytical Systems is an enterprise technical leader responsible for the architectural vision of the "Dry Lab" informatics ecosystem. This role defines how we process, analyze, and interpret massive-scale genomic data—transforming raw sequencing output into life-saving clinical insights.

This strategist owns the long-term technical roadmap for Production Bioinformatics Pipelines and Tertiary Analysis Systems. You will architect the platforms that handle primary/secondary NGS analysis, variant annotation, clinical classification, and the complex orchestration of Clinical Report Writing. Your mission is to ensure our analytical systems are computationally efficient, scientifically rigorous, and compliant with global regulatory standards (FDA/CAP/CLIA).

In the first 90 days, you will:

• Conduct a deep-dive audit of our current bioinformatics infrastructure and reporting workflows.
• Identify bottlenecks in processing latency and manual "scientist-in-the-loop" steps within the tertiary analysis phase.
• Establish a working rapport with the Bioinformatics R&D and Clinical Operation teams to align on a unified "Production-Grade" vision.

Within the first year, you will:

• Architect a scalable, cloud-native framework for "plug-and-play" bioinformatics pipelines that supports our entire portfolio (Oncology MRD/CGP, ECD, and Women’s Health).
• Define success by a measurable reduction in computational cost-per-sample, increased automation in variant classification, and a modernized reporting workflow engine that significantly reduces the time from "Sequence-Complete" to "Report-Issued."

Qualifications

• 10+ years of experience in software architecture or technical strategy, with at least 5 years focused on Bioinformatics, Genomics, or Clinical Data Systems.
• Deep expertise in NGS Data Processing (FastQ to VCF) and the computational challenges of high-throughput primary and secondary analysis.
• Proven experience building or scaling Tertiary Analysis/Interpretation systems, knowledgebases (genetics and/or oncology), and clinical report-writing workflows.
• Exceptional ability to bridge the gap between Geneticists and Software Engineers.

Requirements

• Experience with Oncology diagnostics, specifically MRD (Minimal Residual Disease) or CGP (Comprehensive Genomic Profiling).
• Familiarity with AI/ML integration into clinical decision support systems.
• Advanced degree (Masters or PhD) in Genetics, Computational Biology, or Computer Science.

Work Model & Travel

This is a remote role. Periodic travel to San Carlos, CA and Austin, TX is expected to collaborate with the R&D and Clinical Lab Ops teams.

Compensation

The pay range is listed and actual compensation packages are based on a wide array of factors unique to each candidate, including but not limited to skill set, years & depth of experience, certifications and specific office location. This may differ in other locations due to cost of labor considerations.

• Remote USA: $182,900 — $228,600 USD

Benefits

• Comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents.
• Free testing for Natera employees and their immediate families in addition to fertility care benefits.
• Pregnancy and baby bonding leave.
• 401k benefits.
• Commuter benefits.
• A generous employee referral program.

Company Description

Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives.

The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers and many other professionals from world-class institutions, who care deeply for our work and each other. When you join Natera, you’ll work hard and grow quickly. Working alongside the elite of the industry, you’ll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management.